Recursos

STUDY: A mixed-method analysis of persisting effects associated with positive outcomes following ibogaine detoxification - Davis, Renn, Windham-Herman, Polanco, Barsuglia (2018)

STUDY: A phenomenological investigation into the lived experience of ibogaine and its potential to treat opioid use disorders - Camlin, Eulert, Thomas, Bucky, Barsuglia, Polanco (2018)

PAPER: An end to the opioid epidemic: New study suggests ibogaine treatment could be a game changer - Garcia, Barsuglia (2017)

PAPER: An ibogaine treatment protocol - Geerte for the Lindesmith Centre

THESIS: Breaking the habit: Ibogaine as a viable treatment for opioid dependence and withdrawal - Matthew Styles (2014)

STUDY: Case studies of ibogaine treatment: Implications for patient management strategies - Lotsof, Alexander (2001)

STUDY: Changes in withdrawal and craving scores in participants undergoing opioid detoxification utilizing Ibogaine - Malcolm, Polanco, Barsuglia (2018)

STUDY: Detoxification from methadone using low, repeated, and increasing doses of ibogaine: A case report - Wilkins, Dos Santos, Sola, Aixala, Cura, Moreno, Alcazar-Corcoles, Hallak, Bouso (2017)

THESIS: Experiences of opioid detoxification using ibogaine in various treatment settings - Jamie Walker (2016)

STUDY: Ibogaine and addiction in the animal model, a systematic review of and meta-analysis - Belgers, Leenaars, Homberg, Ritskes-Hoitinga, Schellekens, Hooijmans (2016)

STUDY: Ibogaine as a potential anti-addictive treatment - Nor Ilyani Mohamed Nazar (2014)

STUDY: Ibogaine as an alternative and efficacious treatment for heroin addiction - Amadon, Roecker

STUDY: Ibogaine detoxification transitions opioid and cocaine abusers between dependence and abstinence: Clinical observations and treatment - Mash, Duque, Page, Allen-Ferdinand (2018)

STUDY: Ibogaine effect on cocaine craving and use in dependent patients: A double-blind, placebo-controlled pilot study - Pedro Luis Prior, Sergio Luiz Prior (2014)

STUDY: Ibogaine for opioid use disorder: Can we root out addiction at its source? - Shuang Ouyang (2016)

PAPER: Ibogaine in the treatment of chemical dependence disorders: Clinical perspectives - Howard Lotsof (1995)

STUDY: Ibogaine in the treatment of heroin withdrawal - Mash, Kovera, Pablo (2001)

STUDY: Ibogaine in the treatment of substance dependence - Thomas Kingsley Brown (2013)

THESIS: Ibogaine offers an alternative approach for treating opiate addiction - Christopher Nielsen (2018)

STUDY: Ibogaine treatment outcomes for opioid dependence from a twelve-month follow-up observational study - Noller, Frampton, Yazar-Klosinski (2016)

STUDY: Ibogaine: An anti-addictive drug: Pharmacology and time to go further in development - Maciulaitis, Kontrimaviciute, Bressolle, Briedis (2008)

STUDY: Ibogaine: A novel anti-addictive compound - A comprehensive literature review - Freedlander, DiClemente (2003)

STUDY: Ibogaine: A review - Kenneth Alper (2015)

STUDY: Ibogaine: Treatment outcomes and observations - MAPS (2003)

STUDY: Life after ibogaine: An exploratory study of the long-term effects of ibogaine treatment on drug addicts - Ehud Bastiaans (2004)

STUDY: Mechanisms of action of ibogaine: Relevance to putative therapeutic effects and development of a safer iboga alkaloid congener - Glick, Maisonneuve, Szumlinski (2001)

STUDY: Novel pharmacotherapeutic treatments for cocaine addiction - Daryl Shorter, Thomas Kosten (2011)

STUDY: Receptor binding profile suggests multiple mechanisms of action are responsible for ibogaine's putative anti-addictive activity - Sweetnam, Lancaster, Snowman, Collins, Perschke, Bauer, Ferkany (1994)

STUDY: Remission of severe opioid use disorder with ibogaine: A case report - Cloutier-Gill, Wood, Millar, Ferris, Socias (2016)

STUDY: Subjective effectiveness of ibogaine treatment for problematic opioid consumption: Short- and long-term outcomes - Davis, Barsuglia, Windham-Herman, Lynch, Polanco (2017)

STUDY: The antiaddictive effects of ibogaine: A systematic literature review of human studies - Dos Santos, Bouso, Hallak (2016)

STUDY: The use of ibogaine in the treatment of addictions - Kenneth Alper, Howard Lotsof (2007)

STUDY: Treatment of acute opioid withdrawal with ibogaine - Alper, Lotsof, Frenken, Luciano, Bastiaans (1999)

STUDY: Treatment of opioid use disorder with ibogaine: Detoxification and drug use outcomes - Brown, Alper (2017)

STUDY: Treatment of opioid use disorder with ibogaine_Detoxification and drug use outcomes: Clinical rationale - Brown, Alper (2017)
STUDY: Acute toxicity of ibogaine and noribogaine - Kubiliene, Marksiene, Kazlauskas, Sadauskiene, Razukas, Ivanov - 2008

STUDY: Anti-addiction drug ibogaine inhibits hERG channels: A cardiac arrhythmia risk! - Koenig, Kovar, Boehm, Sandtner, Hilber (2016)

STUDY: Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: A study to assess the drugs' cardiac ion channel profile - Koenig, Kovar, Rubi, Mike, Lukacs, Gawali, Todt, Hilber, Sandtner (2013)

STUDY: Anti-addiction drug ibogaine prolongs the action potential in human induced pluripotent stem cell-derived cardiomyocytes - Rubi, Eckert, Boehm, Hilber, Koenig (2016)

STUDY: Cardiac arrest after ibogaine intoxication - Steinberg, Deyell - 2018

STUDY: Clinical updates on drug-induced cardiotoxicity - Ashif Iqubal, Mohammad Kashif Iqubal, Syed Ehtaishamul Haque, Sumit Sharma, Mohd. Asif Ansari, Vasim Khan - 2018

STUDY: Distribution of ibogaine and noribogaine in a man following a poisoning involving root bark of the Tabernanthe iboga shrub - Kontrimaviciute, Mathieu, Mathieu-Daud, Vainauskas, Casper, Baccino, Bressolle (2006)

STUDY: Effect of iboga alkaloids on μ-Opioid receptor-coupled G protein activation - Antonio, Childers, Rothman, Dersch, Kuehne, Bornmann, Eshleman, Janowsky, King, Simon, Reith, Alper (2013)

STUDY: Fatal case of a 27-year-old male after taking iboga in withdrawal - Mazoyer, Carlier, Boucher, Peoc, Lemeur, Gaillard (2013)

STUDY: Fatalities after taking ibogaine in addiction treatment could be related to sudden cardiac death caused by autonomic dysfunction - Maas, Strubelt (2006)

STUDY: Fatalities temporally associated with the ingestion of ibogaine - Alper, Stajic, Gill (2012)

STUDY: Herbal Seizures: Atypical symptoms after ibogaine intoxication: A case report - Breuer, Kasper, Schwarze, Gschossmann, Kornhuber, Müller (2015)

STUDY: hERG blockade by iboga alkaloids - Alper, Fowler, Ruan, Bai, Liu, Huang, Priori (2015)

STUDY: Ibogaine neurotoxicity assessment: Electrophysiological, neurochemical and neurohistological methods - Binienda, Scallet, Schmued, Ali (2001)

STUDY: Ibogaine-associated cardiac arrest and death: Case report and review of the literature - Meisner, Wilcox, Richards (2016)

STUDY: Ibogaine-associated ventricular tachyarrhythmias - Pleskovic, Gorjup, Brvar, Kozelj (2012)

STUDY: Ibogaine-related sudden death: A case report - Papadodima, Dona, Evaggelakos, Goutas, Athanaselis (2013)

STUDY: Life-threatening complications of ibogaine: Three case reports - Paling, Andrews, Valk, Blom (2012)

STUDY: Long-QT syndrome induced by the anti-addiction drug ibogaine - Dianne Hoelen (2009)

STUDY: Mechanism of hERG channel block by the psychoactive indole alkaloid ibogaine - Thurner, Stary-Weinzinger, Gafar, Gawali, Kudlacek, Zezula, Hilber, Boehm, Sandtner, Koenig (2014)

STUDY: Opioid treatment and long QT syndrome: A critical review of the literature - Pacini, Maremmani, Dell’Osso, Maremmani (2009)

STUDY: QT interval prolongation and the risk of Torsades de Pointes - Trinkley, Page, Lien, Yamanouye, Tisdale (2013)

STUDY: Pathophysiology of the long QT syndrome - Peter Zimetbaum (2019)

STUDY: Pharmacokinetics of hERG channel blocking - Christina Mair (2016)

STUDY: Predicting drug-induced changes in QT interval and arrhythmias - Lu, Vlaminckx, Hermans, Rohrbacher, Van Ammel, Towart, Pugsley, Gallacher - 2008

STUDY: Predicting the unpredictable: Drug-induced QT prolongation and Torsades de Pointes - Schwartz, Woosley - 2016

STUDY: QTc prolongation by psychotropic drugs and the risk of Torsade de Pointes - Wenzel-Seifert, Wittmann, Haen (2011)

STUDY: The anti-addiction drug ibogaine and the heart: A delicate relation - Koenig, Hilber (2015)

STUDY: The anti-addiction drug ibogaine inhibits cardiac ion channels: A study to assess the drug's pro-arrhythmic potential - Koenig, Hilber (2012)

STUDY: The anti-addictive drug ibogaine modulates voltage-gated ion channels and may trigger cardiac arrythmias - Kovar, Koenig, Mike, Cervenka, Lukács, Todt, Sandtner, Hilber (2011)

STUDY: Toxicokinetics of ibogaine and noribogaine in a patient with prolonged multiple cardiac arrhythmias after ingestion of internet purchased ibogaine - Henstra, Wong, Chahbouni, Swart, Allaart, Sombogaard (2017)
STUDY: A community-based evaluation of sudden death associated with therapeutic levels of methadone - Chugh, Socoteanu, Reinier, Waltz, Jui, Gunson (2008)

STUDY: A phenomenological analysis of the subjective experience elicited by ibogaine in the context of a drug dependence treatment - Schenberg, de Castro Comis, Alexandre, Tofoli, da Silveira (2017)

STUDY: A systematic review of the cardiotoxicity of methadone - Alinejad, Kazemi, Zamani, Hoffman, Mehrpour (2015)

STUDY: Acquired QT interval prolongation and methadone: The risk of pharmacological interaction - Digby, Fong, Methot, Simpson, Redfearn, Baranchuk (2011)

STUDY: Characterizing QT interval prolongation in early clinical development: A case study with methadone - Dubois, Danhof, Pasqua (2016)

STUDY: Chronic racemic and s-methadone treatment reduces hERG gene expression in human primary cardiomyocytes - Mokhtar, Hussin (2017)

STUDY: Comprehensive review on methadone-induced QT prolongation and Torsades - Treece, Al Madani, El Khoury, Khraisha, Martin, Braumrucker, Neglia, Paul (2018)

STUDY: Drug-induced long QT syndrome in injection drug users receiving methadone - (2006)

STUDY: Measurement of QTc in patients receiving chronic methadone therapy - Cruciani, Sekine, Homel, Lussier, Yap, Suzuki, Schweitzer, Yancovitz, Lapin, Shaiova, Sheu, Portenoy (2005)

STUDY: Methadone and QTc prolongation - Habershaw, Weisbrod (2012)

STUDY: Methadone safety: A clinical practice guideline - Chou, Cruciani, Haigney, Marcus, Fiellin, Inturrisi, Knight, Mehta, Savage, Strain, Compton, Meyer, Walsh, Otis-Green, Farrar, Portenoy, Zeltzer (2014)

STUDY: Methadone, QTc interval prolongation and Torsade de Pointes: Case reports offer the best understanding of this problem - Vieweg, Hasnain, Howland, Clausen, Koneru, Kogut, Crouse, Hancox, Fernandez, Pandurangi (2013)

STUDY: Methadone, QTc prolongation and Torsades de Pointes: Current concepts, management and a hidden twist in the tale - Mujtaba, Romero, Taub (2013)

STUDY: Methadone-associated QT interval prolongation and Torsades de Pointes - Stringer, Welsh, Tommasello (2009)

STUDY: Methadone-induced QTc prolongation - Wong, Roberts (2007)

STUDY: QT interval prolongation and the risk of Torsades de Pointes - Trinkley, Page, Lien, Yamanouye, Tisdale (2013)

STUDY: QT interval screening in methadone maintenance treatment: Report of a SAMHSA expert panel - Martin, Campbell, Killip, Kotz, Krantz, Kreek, McCarroll, Mehta, Payte, Stimmel, Taylor, Haigney, Wilford (2012)

STUDY: QT prolongation and arrhythmia risk in methadone maintenance treatment - Barbhaiya, Seewald, Hanon (2011)

STUDY: QTc interval screening in methadone treatment - Krantz, Martin, Stimmel, Mehta, Haigney (2009)

STUDY: Torsade de Pointes due to methadone use in a patient with HIV and Hepatitis C coinfection - John, Amley, Bombino, Gitelis, Topi, Hollander, Ghosh (2010)
BOOK: Alkaloids: Secrets of Life - Tadeusz Aniszewski (2007)

STUDY: Anti-hERG activity and the risk of drug-induced arrythmias and sudden death - De Bruin, Pettersson, Meyboom, Hoes, Leufkens (2004)

STUDY: Biosynthesis of an anti-addiction agent from the iboga plant - Farrow, McAtee, Kamileen, Stephenson, Caputi, Bussey, O’Connor (2019)

STUDY: Characterization of multiple sites of action of ibogaine - Sershen, Hashim, Lajth (2001)

STUDY: Chemistry and biology of the genus Voacanga - Hussain et al. (2012)

STUDY: Comparative neuropharmacology of ibogaine and its O-desmethyl metabolite, noribogaine - Baumann, Pablo, Ali, Rothman, Mash (2001)

STUDY: Cytochrome P450 and O-methyltransferase catalyze the final steps in the biosynthesis of the anti-addictive alkaloid ibogaine from tabernanthe iboga - Farrow, Kamileen, Meades, Ameyaw, Xiao, O'Connor (2018)

STUDY: Discovery of the final steps in ibogaine biosynthesis - Farrow, Kamileen, Meades, Ameyaw, Xiao, O'Connor (2018)

STUDY: Drug-induced QT prolongation and Torsades de Pointes - Li, Ramos (2017)

STUDY: Effect of iboga alkaloids on u-opioid receptor-coupled g protein activation - Antonio, Childers, Rothman, Dersch, Kuehne, Bornmann, Eshleman, Janowsky, King, Simon, Reith, Alper (2013)

STUDY: Enantioselective synthesis of Iboga alkaloids and vinblastine via rearrangements of quaternary ammoniums - Zhang, Xue, Li, Yuan, Luo (2016)

STUDY: Facilitation of hERG channels by blockers: A mechanism predicted to reduce lethal cardiac arrythmias - Furutani, Tsumoto, Chen, Handa, Yamakawa, Sack, Yurachi (2018)

STUDY: How toxic is ibogaine? - Litjens, Brunt (2016)

STUDY: Ibogaine 12-methoxyibogamine synthesis - Shulgin

STUDY: Ibogaine and a total alkaloid extract of voacanga africana modulate neuronal excitability and synaptic transmission - Kombian, Saleh, Fiagbre, Chen, Akabutu, Buolamwini, Pittman (1997)

STUDY: Ibogaine and noribogaine: Comparing parent compound to metabolite - Carlos Zubaran (2000)

STUDY: Ibogaine and the inhibition of acetylcholinesterase - Alper, Reith, Sershen (2012)

STUDY: Ibogaine TA/HCL extraction TEK - MindVox (2010)

STUDY: Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter - Jacobs, Zhang, Campbell, Rudnick (2007)

STUDY: Ibogaine: Complex pharmacokinetics, concerns for safety, and preliminary efficacy measures - Mask, Kovera, Pablo, Tyndale, Ervin, Williams, Singleton, Mayor (2000)

STUDY: Mechanisms of action of ibogaine: Relevance to putative therapeutic effects and development of a safer iboga alkaloid congener - Glick, Maisonneuve, Szumlinski (2001)

STUDY: Morphing of ibogaine: A successful attempt into the search for sigma-2 receptor ligands - Floresta, Dichiara, Gentile, Prezzavento, Marrazzo, Rescifina, Amata (2019)

STUDY: Natural products modulating the hERG channel - Kratz et. al. (2017)

STUDY: Novel strategy to transform a commercially available iboga alkaloid to post-iboga alkaloids - Han et. al. (2018)

STUDY: Pharmacology of ibogaine and ibogaine-related alkaloids - Popik, Skolnick (1998)

STUDY: Predicting drug-induced changes in QT interval arrhythmias - Lu, Vlaminckx, Hermans, Rohrbacher, Van Ammel, Towart, Gallacher (2008)

STUDY: Progress in the synthesis of iboga-alkaloids and their congeners - Jana, Paul, Sinha (2011)

STUDY: Properties of ibogaine and its principal metabolite 12-hydroxyibogamine - Mash, Staley, Pablo, Holohean, Hackman, Davidoff (1995)

STUDY: Receptor binding profile suggests multiple mechanisms of action are responsible for ibogaine's putative anti-addictive activity - Sweetnam, Lancaster, Snowman, Collins, Perschke, Bauer, Ferkany (1994)

STUDY: The Alkaloids: Chemistry and Biology - Cordell (1993)

STUDY: The Iboga alkaloids - Lavaud, Massiot (2017)

STUDY: The Iboga and Voacanga alkaloids - Taylor (1965)

STUDY: The neurobiology of opioid dependence - Kosten, George (2002)

STUDY: The putative anti-addictive drug ibogaine is a competitive inhibitor of [3H]MK-801 binding to the NMDA receptor complex - Popik, Layer, Skolnick (1994)

STUDY: Total synthesis of ibogaine, epiibogaine and their analogues - Goutam Kumar Jana, Surajit Sinha (2012)
Dr. Bruno Chaves, on Treating Cocaine Addiction with Ibogaine

Is Ibogaine Treatment in Brazil Finally Stepping Out From the Underground?(2017)

Dr. Bruno Chaves speaks at MAPS' 2017 Psychedelic Science Conference in Oakland, California (2017)

STUDY: Clinical guidelines for ibogaine-assisted detoxification - Dickinson, McAlpin, Wilkins, Fitzsimmons, Guion, Paterson, Greene, Chaves (2015)

STUDY: Treating drug dependence with the aid of ibogaine: A qualitative study - Schenberg, de Castro Comis, Alexandre, Chaves, T́ogoli, Dartiu, da Silveira (2016)

STUDY: Treating drug dependence with the aid of ibogaine: A retrospective study - Schenberg, de Castro Comis, Chaves, da Silveira (2014)
GITA: Global Ibogaine Therapy Alliance

ICEERS: International Center for Ethnobotanical Education
AEDMP: Bibliography of iboga scientific papers - Cristian Mantilla, Genis Ona (2014)

ICEERS: Ibogaine Scientific Literature Overview - International Center for Ethnobotanical Education, Research & Service - Bouso, Alper (2012)

The Ibogaine Dossier: Manual for Ibogaine Therapy - Screening, Safety, Monitoring & Aftercare - Lotsof, Wachtel (2003)