Recursos

STUDY: A mixed-method analysis of persisting effects associated with positive outcomes following ibogaine detoxification - Davis, Renn, Windham-Herman, Polanco, Barsuglia (2018)

STUDY: A phenomenological analysis of the subjective experience elicited by ibogaine in the context of a drug dependence treatment - Schenberg, de Castro Comis, Alexandre, Tofoli, Chaves, da Silveira (2017)

STUDY: A phenomenological investigation into the lived experience of ibogaine and its potential to treat opioid use disorders - Camlin, Eulert, Thomas, Bucky, Barsuglia, Polanco (2018)

PAPER: An end to the opioid epidemic: New study suggests ibogaine treatment could be a game changer - Garcia, Barsuglia (2017)

PAPER: An ibogaine treatment protocol - Geerte for the Lindesmith Centre

THESIS: Breaking the habit: Ibogaine as a viable treatment for opioid dependence and withdrawal - Matthew Styles (2014)

STUDY: Case studies of ibogaine treatment: Implications for patient management strategies - Lotsof, Alexander (2001)

STUDY: Changes in withdrawal and craving scores in participants undergoing opioid detoxification utilizing Ibogaine - Malcolm, Polanco, Barsuglia (2018)

STUDY: Clinical guidelines for ibogaine-assisted detoxification - Dickinson, McAlpin, Wilkins, Fitzsimmons, Guion, Paterson, Greene, Chaves (2016)

STUDY: Detoxification from methadone using low, repeated, and increasing doses of ibogaine: A case report - Wilkins, Dos Santos, Sola, Aixala, Cura, Moreno, Alcazar-Corcoles, Hallak, Bouso (2017)

THESIS: Experiences of opioid detoxification using ibogaine in various treatment settings - Jamie Walker (2016)

STUDY: Ibogaine and addiction in the animal model, a systematic review of and meta-analysis - Belgers, Leenaars, Homberg, Ritskes-Hoitinga, Schellekens, Hooijmans (2016)

STUDY: Ibogaine as a potential anti-addictive treatment - Nor Ilyani Mohamed Nazar (2014)

STUDY: Ibogaine as an alternative and efficacious treatment for heroin addiction - Amadon, Roecker

STUDY: Ibogaine detoxification transitions opioid and cocaine abusers between dependence and abstinence: Clinical observations and treatment - Mash, Duque, Page, Allen-Ferdinand (2018)

STUDY: Ibogaine effect on cocaine craving and use in dependent patients: A double-blind, placebo-controlled pilot study - Pedro Luis Prior, Sergio Luiz Prior (2014)

STUDY: Ibogaine for opioid use disorder: Can we root out addiction at its source? - Shuang Ouyang (2016)

PAPER: Ibogaine in the treatment of chemical dependence disorders: Clinical perspectives - Howard Lotsof (1995)

STUDY: Ibogaine in the treatment of heroin withdrawal - Mash, Kovera, Pablo (2001)

STUDY: Ibogaine in the treatment of substance dependence - Thomas Kingsley Brown (2013)

THESIS: Ibogaine offers an alternative approach for treating opiate addiction - Christopher Nielsen (2018)

STUDY: Ibogaine treatment outcomes for opioid dependence from a twelve-month follow-up observational study - Noller, Frampton, Yazar-Klosinski (2016)

STUDY: Ibogaine: An anti-addictive drug: Pharmacology and time to go further in development - Maciulaitis, Kontrimaviciute, Bressolle, Briedis (2008)

STUDY: Ibogaine: A novel anti-addictive compound - A comprehensive literature review - Freedlander, DiClemente (2003)

STUDY: Ibogaine: A review - Kenneth Alper (2015)

STUDY: Ibogaine: Treatment outcomes and observations - MAPS (2003)

STUDY: Life after ibogaine: An exploratory study of the long-term effects of ibogaine treatment on drug addicts - Ehud Bastiaans (2004)

STUDY: Mechanisms of action of ibogaine: Relevance to putative therapeutic effects and development of a safer iboga alkaloid congener - Glick, Maisonneuve, Szumlinski (2001)

STUDY: Novel pharmacotherapeutic treatments for cocaine addiction - Daryl Shorter, Thomas Kosten (2011)

STUDY: Receptor binding profile suggests multiple mechanisms of action are responsible for ibogaine's putative anti-addictive activity - Sweetnam, Lancaster, Snowman, Collins, Perschke, Bauer, Ferkany (1994)

STUDY: Remission of severe opioid use disorder with ibogaine: A case report - Cloutier-Gill, Wood, Millar, Ferris, Socias (2016)

STUDY: Subjective effectiveness of ibogaine treatment for problematic opioid consumption: Short- and long-term outcomes - Davis, Barsuglia, Windham-Herman, Lynch, Polanco (2017)

STUDY: The antiaddictive effects of ibogaine: A systematic literature review of human studies - Dos Santos, Bouso, Hallak (2016)

STUDY: The use of ibogaine in the treatment of addictions - Kenneth Alper, Howard Lotsof (2007)

STUDY: Treating drug dependence with the aid of ibogaine: A qualitative study - Schenberg, de Castro Comis, Alexandre, Chaves, T́ogoli, Dartiu, da Silveira (2016)

STUDY: Treating drug dependence with the aid of ibogaine: A retrospective study - Schenberg, de Castro Comis, Chaves, da Silveira (2014)

STUDY: Treatment of acute opioid withdrawal with ibogaine - Alper, Lotsof, Frenken, Luciano, Bastiaans (1999)

STUDY: Treatment of opioid use disorder with ibogaine: Detoxification and drug use outcomes - Brown, Alper (2017)

STUDY: Treatment of opioid use disorder with ibogaine_Detoxification and drug use outcomes: Clinical rationale - Brown, Alper (2017)
STUDY: Acute toxicity of ibogaine and noribogaine - Kubiliene, Marksiene, Kazlauskas, Sadauskiene, Razukas, Ivanov (2008)

STUDY: Anti-addiction drug ibogaine inhibits hERG channels: A cardiac arrhythmia risk! - Koenig, Kovar, Boehm, Sandtner, Hilber (2016)

STUDY: Anti-addiction drug ibogaine inhibits voltage-gated ionic currents: A study to assess the drugs' cardiac ion channel profile - Koenig, Kovar, Rubi, Mike, Lukacs, Gawali, Todt, Hilber, Sandtner (2013)

STUDY: Anti-addiction drug ibogaine prolongs the action potential in human induced pluripotent stem cell-derived cardiomyocytes - Rubi, Eckert, Boehm, Hilber, Koenig (2016)

STUDY: Cardiac arrest after ibogaine intoxication - Steinberg, Deyell (2018)

STUDY: Clinical updates on drug-induced cardiotoxicity - Ashif Iqubal, Mohammad Kashif Iqubal, Syed Ehtaishamul Haque, Sumit Sharma, Mohd. Asif Ansari, Vasim Khan (2018)

STUDY: Distribution of ibogaine and noribogaine in a man following a poisoning involving root bark of the Tabernanthe iboga shrub - Kontrimaviciute, Mathieu, Mathieu-Daud, Vainauskas, Casper, Baccino, Bressolle (2006)

STUDY: Effect of iboga alkaloids on μ-Opioid receptor-coupled G protein activation - Antonio, Childers, Rothman, Dersch, Kuehne, Bornmann, Eshleman, Janowsky, King, Simon, Reith, Alper (2013)

STUDY: Fatal case of a 27-year-old male after taking iboga in withdrawal - Mazoyer, Carlier, Boucher, Peoc, Lemeur, Gaillard (2013)

STUDY: Fatalities after taking ibogaine in addiction treatment could be related to sudden cardiac death caused by autonomic dysfunction - Maas, Strubelt (2006)

STUDY: Fatalities temporally associated with the ingestion of ibogaine - Alper, Stajic, Gill (2012)

STUDY: Herbal Seizures: Atypical symptoms after ibogaine intoxication: A case report - Breuer, Kasper, Schwarze, Gschossmann, Kornhuber, Müller (2015)

STUDY: hERG blockade by iboga alkaloids - Alper, Fowler, Ruan, Bai, Liu, Huang, Priori (2015)

STUDY: Ibogaine neurotoxicity assessment: Electrophysiological, neurochemical and neurohistological methods - Binienda, Scallet, Schmued, Ali (2001)

STUDY: Ibogaine-associated cardiac arrest and death: Case report and review of the literature - Meisner, Wilcox, Richards (2016)

STUDY: Ibogaine-associated ventricular tachyarrhythmias - Pleskovic, Gorjup, Brvar, Kozelj (2012)

STUDY: Ibogaine-related sudden death: A case report - Papadodima, Dona, Evaggelakos, Goutas, Athanaselis (2013)

STUDY: Life-threatening complications of ibogaine: Three case reports - Paling, Andrews, Valk, Blom (2012)

STUDY: Long-QT syndrome induced by the anti-addiction drug ibogaine - Dianne Hoelen (2009)

STUDY: Mechanism of hERG channel block by the psychoactive indole alkaloid ibogaine - Thurner, Stary-Weinzinger, Gafar, Gawali, Kudlacek, Zezula, Hilber, Boehm, Sandtner, Koenig (2014)

STUDY: Opioid treatment and long QT syndrome: A critical review of the literature - Pacini, Maremmani, Dell’Osso, Maremmani (2009)

STUDY: QT interval prolongation and the risk of Torsades de Pointes - Trinkley, Page, Lien, Yamanouye, Tisdale (2013)

STUDY: Pathophysiology of the long QT syndrome - Peter Zimetbaum (2019)

STUDY: Pharmacokinetics of hERG channel blocking - Christina Mair (2016)

STUDY: Predicting drug-induced changes in QT interval and arrhythmias - Lu, Vlaminckx, Hermans, Rohrbacher, Van Ammel, Towart, Pugsley, Gallacher (2008)

STUDY: Predicting the unpredictable: Drug-induced QT prolongation and Torsades de Pointes - Schwartz, Woosley (2016)

STUDY: QTc prolongation by psychotropic drugs and the risk of Torsade de Pointes - Wenzel-Seifert, Wittmann, Haen (2011)

STUDY: The anti-addiction drug ibogaine and the heart: A delicate relation - Koenig, Hilber (2015)

STUDY: The anti-addiction drug ibogaine inhibits cardiac ion channels: A study to assess the drug's pro-arrhythmic potential - Koenig, Hilber (2012)

STUDY: The anti-addictive drug ibogaine modulates voltage-gated ion channels and may trigger cardiac arrythmias - Kovar, Koenig, Mike, Cervenka, Lukács, Todt, Sandtner, Hilber (2011)

STUDY: Toxicokinetics of ibogaine and noribogaine in a patient with prolonged multiple cardiac arrhythmias after ingestion of internet purchased ibogaine - Henstra, Wong, Chahbouni, Swart, Allaart, Sombogaard (2017)
STUDY: A community-based evaluation of sudden death associated with therapeutic levels of methadone - Chugh, Socoteanu, Reinier, Waltz, Jui, Gunson (2008)

STUDY: A systematic review of the cardiotoxicity of methadone - Alinejad, Kazemi, Zamani, Hoffman, Mehrpour (2015)

STUDY: Acquired QT interval prolongation and methadone: The risk of pharmacological interaction - Digby, Fong, Methot, Simpson, Redfearn, Baranchuk (2011)

STUDY: Characterizing QT interval prolongation in early clinical development: A case study with methadone - Dubois, Danhof, Pasqua (2016)

STUDY: Chronic racemic and s-methadone treatment reduces hERG gene expression in human primary cardiomyocytes - Mokhtar, Hussin (2017)

STUDY: Comprehensive review on methadone-induced QT prolongation and Torsades - Treece, Al Madani, El Khoury, Khraisha, Martin, Braumrucker, Neglia, Paul (2018)

STUDY: Drug-induced long QT syndrome in injection drug users receiving methadone - (2006)

STUDY: Measurement of QTc in patients receiving chronic methadone therapy - Cruciani, Sekine, Homel, Lussier, Yap, Suzuki, Schweitzer, Yancovitz, Lapin, Shaiova, Sheu, Portenoy (2005)

STUDY: Methadone and QTc prolongation - Habershaw, Weisbrod (2012)

STUDY: Methadone safety: A clinical practice guideline - Chou, Cruciani, Haigney, Marcus, Fiellin, Inturrisi, Knight, Mehta, Savage, Strain, Compton, Meyer, Walsh, Otis-Green, Farrar, Portenoy, Zeltzer (2014)

STUDY: Methadone, QTc interval prolongation and Torsade de Pointes: Case reports offer the best understanding of this problem - Vieweg, Hasnain, Howland, Clausen, Koneru, Kogut, Crouse, Hancox, Fernandez, Pandurangi (2013)

STUDY: Methadone, QTc prolongation and Torsades de Pointes: Current concepts, management and a hidden twist in the tale - Mujtaba, Romero, Taub (2013)

STUDY: Methadone-associated QT interval prolongation and Torsades de Pointes - Stringer, Welsh, Tommasello (2009)

STUDY: Methadone-induced QTc prolongation - Wong, Roberts (2007)

STUDY: QT interval prolongation and the risk of Torsades de Pointes - Trinkley, Page, Lien, Yamanouye, Tisdale (2013)

STUDY: QT interval screening in methadone maintenance treatment: Report of a SAMHSA expert panel - Martin, Campbell, Killip, Kotz, Krantz, Kreek, McCarroll, Mehta, Payte, Stimmel, Taylor, Haigney, Wilford (2012)

STUDY: QT prolongation and arrhythmia risk in methadone maintenance treatment - Barbhaiya, Seewald, Hanon (2011)

STUDY: QTc interval screening in methadone treatment - Krantz, Martin, Stimmel, Mehta, Haigney (2009)

STUDY: Torsade de Pointes due to methadone use in a patient with HIV and Hepatitis C coinfection - John, Amley, Bombino, Gitelis, Topi, Hollander, Ghosh (2010)
BOOK: Alkaloids: Secrets of Life - Tadeusz Aniszewski (2007)

STUDY: Anti-hERG activity and the risk of drug-induced arrythmias and sudden death - De Bruin, Pettersson, Meyboom, Hoes, Leufkens (2004)

STUDY: Biosynthesis of an anti-addiction agent from the iboga plant - Farrow, McAtee, Kamileen, Stephenson, Caputi, Bussey, O’Connor (2019)

STUDY: Characterization of multiple sites of action of ibogaine - Sershen, Hashim, Lajth (2001)

STUDY: Chemistry and biology of the genus Voacanga - Hussain et al. (2012)

STUDY: Comparative neuropharmacology of ibogaine and its O-desmethyl metabolite, noribogaine - Baumann, Pablo, Ali, Rothman, Mash (2001)

STUDY: Cytochrome P450 and O-methyltransferase catalyze the final steps in the biosynthesis of the anti-addictive alkaloid ibogaine from tabernanthe iboga - Farrow, Kamileen, Meades, Ameyaw, Xiao, O'Connor (2018)

STUDY: Discovery of the final steps in ibogaine biosynthesis - Farrow, Kamileen, Meades, Ameyaw, Xiao, O'Connor (2018)

STUDY: Drug-induced QT prolongation and Torsades de Pointes - Li, Ramos (2017)

STUDY: Effect of iboga alkaloids on u-opioid receptor-coupled g protein activation - Antonio, Childers, Rothman, Dersch, Kuehne, Bornmann, Eshleman, Janowsky, King, Simon, Reith, Alper (2013)

STUDY: Enantioselective synthesis of Iboga alkaloids and vinblastine via rearrangements of quaternary ammoniums - Zhang, Xue, Li, Yuan, Luo (2016)

STUDY: Facilitation of hERG channels by blockers: A mechanism predicted to reduce lethal cardiac arrythmias - Furutani, Tsumoto, Chen, Handa, Yamakawa, Sack, Yurachi (2018)

STUDY: How toxic is ibogaine? - Litjens, Brunt (2016)

STUDY: Ibogaine 12-methoxyibogamine synthesis - Shulgin

STUDY: Ibogaine and a total alkaloid extract of voacanga africana modulate neuronal excitability and synaptic transmission - Kombian, Saleh, Fiagbre, Chen, Akabutu, Buolamwini, Pittman (1997)

STUDY: Ibogaine and noribogaine: Comparing parent compound to metabolite - Carlos Zubaran (2000)

STUDY: Ibogaine and the inhibition of acetylcholinesterase - Alper, Reith, Sershen (2012)

STUDY: Ibogaine TA/HCL extraction TEK - MindVox (2010)

STUDY: Ibogaine, a noncompetitive inhibitor of serotonin transport, acts by stabilizing the cytoplasm-facing state of the transporter - Jacobs, Zhang, Campbell, Rudnick (2007)

STUDY: Ibogaine: Complex pharmacokinetics, concerns for safety, and preliminary efficacy measures - Mask, Kovera, Pablo, Tyndale, Ervin, Williams, Singleton, Mayor (2000)

STUDY: Mechanisms of action of ibogaine: Relevance to putative therapeutic effects and development of a safer iboga alkaloid congener - Glick, Maisonneuve, Szumlinski (2001)

STUDY: Morphing of ibogaine: A successful attempt into the search for sigma-2 receptor ligands - Floresta, Dichiara, Gentile, Prezzavento, Marrazzo, Rescifina, Amata (2019)

STUDY: Natural products modulating the hERG channel - Kratz et. al. (2017)

STUDY: Novel strategy to transform a commercially available iboga alkaloid to post-iboga alkaloids - Han et. al. (2018)

STUDY: Pharmacology of ibogaine and ibogaine-related alkaloids - Popik, Skolnick (1998)

STUDY: Predicting drug-induced changes in QT interval arrhythmias - Lu, Vlaminckx, Hermans, Rohrbacher, Van Ammel, Towart, Gallacher (2008)

STUDY: Progress in the synthesis of iboga-alkaloids and their congeners - Jana, Paul, Sinha (2011)

STUDY: Properties of ibogaine and its principal metabolite 12-hydroxyibogamine - Mash, Staley, Pablo, Holohean, Hackman, Davidoff (1995)

STUDY: Receptor binding profile suggests multiple mechanisms of action are responsible for ibogaine's putative anti-addictive activity - Sweetnam, Lancaster, Snowman, Collins, Perschke, Bauer, Ferkany (1994)

STUDY: The Alkaloids: Chemistry and Biology - Cordell (1993)

STUDY: The Iboga alkaloids - Lavaud, Massiot (2017)

STUDY: The Iboga and Voacanga alkaloids - Taylor (1965)

STUDY: The neurobiology of opioid dependence - Kosten, George (2002)

STUDY: The putative anti-addictive drug ibogaine is a competitive inhibitor of [3H]MK-801 binding to the NMDA receptor complex - Popik, Layer, Skolnick (1994)

STUDY: Total synthesis of ibogaine, epiibogaine and their analogues - Goutam Kumar Jana, Surajit Sinha (2012)
Dr. Bruno Rasmussen Chaves

BLUELIGHT: Ibogaine and cocaine addiction

BLUELIGHT: Ibogaine and opiate/opioid addiction

BLUELIGHT: Ibogaine and methamphetamine addiction
GITA: Global Ibogaine Therapy Alliance

ICEERS: International Center for Ethnobotanical Education
AEDMP: Bibliography of iboga scientific papers - Cristian Mantilla, Genis Ona (2014)

GITA: Clinical Guidelines for Ibogaine-assisted Detoxification - Dickenson, McAlpin, Wilkins, Fitzsimmons, Guion, Paterson, Greene, Chaves (2016)

ICEERS: Ibogaine Scientific Literature Overview - International Center for Ethnobotanical Education, Research & Service - Bouso, Alper (2012)

The Ibogaine Dossier: Manual for Ibogaine Therapy - Screening, Safety, Monitoring & Aftercare - Lotsof, Wachtel (2003)